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Kolesterol Normal
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Kolesterol Normal Wanita Dan Pria, kolesterol adalah jenis penting dari lemak yang dibawa dalam darah, tetapi jika berlebih akan beresiko timbulnya penyakit arteri koroner. Menjaga kolesterol anda dengan menjaga pola makan dan gaya hidup yang sehat dapat membantu mengurangi kadar kolesterol anda.
Apa Itu Kolesterol ?
Kolesterol adalah jenis penting dari lemak yang dibawa dalam darah, semua sel dalam tubuh membutuhkan kolesterol untuk membran internal dan eksternal. Hal ini juga diperlukan untuk memproduksi beberapa hormon dan untuk fungsi lain. Terlalu banyak kolesterol dalam darah akan mengakibatkan kerusakan pada arteri dan menyebabkan penyakit jantung.
3/4 kolesterol dalam tubuh anda, dibuat pada organ hati dan sisanya berasal dari jenis lemak yang kita makan. Makan terlalu banyak lemak jenuh dapat menyebabkan kelebihan kolesterol dalam aliran darah.
Kolesterol Baik dan Buruk
Kolesterol dibawa dalam aliran darah di partikel yang disebut lipoprotein. Berikut partikel yang terdapat dalam aliran darah manusia :
Partikel-partikel yang sangat besar disebut Very Low Density Lipoprotein (VLDL)
Partikel yang memiliki ukuran menengah disebut Low Density Lipoprotein (LDL), partikel ini dapat menyebabkan penyakit jantung apabila berlebih, dan
Partikel terkecil disebut High Density Lipoprotein (HDL), partikel ini berguna dalam tubuh dan tidak menyebabkan timbulnya penyakit jantung.
Mengapa Kolesterol Tinggi Menjadi Masalah ?
Kolesterol darah tinggi merupakan salah satu faktor resiko penyakit arteri koroner (serangan jantung dan angina). Jika kadar kolesterol anda adalah 6.5 mmol/L atau lebih, resiko penyakit jantung adalah sekitar empat kali lebih besar dari seseorang dengan kolesterol dari 4 mmol/L. Namun tidak semua orang dengan kadar kolesterol tinggi dapat terkena penyakit jantung.
30% dari masyarakat akan meninggal karena penyakit jantung dan sebagian besar berusia lebih dari 65 tahun, cara paling efektif untuk menurunkan kolesterol LDL anda adalah dengan mengurangi jumlah lemak jenuh dan mengikuti diet sehat, anda bisa melakukan beberapa metode berikut :
Membatasi mengkonsumsi kue dan biskuit.
Pilih susu rendah lemak.
Gunakan margarin atau minyak tak jenuh sebagai pengganti mentega.
Pilih bagian daging yang bebas dari lemak.
Hilangkan bagian lemak dari daging ayam.
Banyak mengkonsumsi ikan dan kacang-kacangan dalam makanan.
Diusahakan untuk menurunkan berat badan jika memiliki kelebihan berat badan.
Jika memiliki kelebihan kolesterol dalam darah, dapat mengakibatkan menempelnya pada dinding arteri. Ketika kolesterol melekat pada dinding arteri yang bisa disebut dengan plak, secara bertahap mengalami penumpukan maka akan mempersempit arteri dan bahkan dapat memblokir saluran darah, jika arteri yang memasok darah ke otot-otot dalam hati tersumbat, serangan jantung bisa terjadi. Dan jika arteri yang memasok darah ke otak tersumbat, stroke dapat terjadi.
Faktor utama resiko yang mempengaruhi LDL anda :
Merokok
Tekanan darah tinggi (140/90 mmHg atau lebih tinggi)
Rendah kolesterol HDL (kurang dari 40mg/ dL)
Riwayat keluarga mempunyai penyakit jantung dini.
Umur (laki-laki 45 tahun atau lebih tua, wanita 55 tahun atau lebih tua)
Ukuran Kolesterol Normal
Kolesterol normal pria dan wanita dapat diukur dengan melihat tabel berikut.
Lihat bagaimana angka kolesterol anda dibandingkan dengan tabel di bawah ini :
Total Tingkat Kolesterol
Kategori
Kurang dari 200mg/dL
Normal
200-239 mg/dL
Batas Tinggi
240mg/dL dan lebih tinggi
Tinggi
LDL (Buruk) Tingkat Kolesterol
LDL Tingkat Kolesterol
Kurang dari 100mg/dL
Optimal
100-129mg/dL
Mendekati Optimal/ Diatas Optimal
130-159 mg/dL
Batas Tinggi
160-189 mg/dL
Tinggi
190 mg/dL and lebih tinggi
Sangat Tinggi
HDL (Baik) Tingkat Kolesterol
HDL Tingkat Kolesterol
Kurang dari 40 mg/dL
Faktor resiko utama penyakit jantung
4059 mg/dL
Semakin tinggi, semakin baik
60 mg/dL dan lebih tinggi
Semakin baik karena terhindar dari resiko penyakit jantung
Sumber : National Heart, Lung, and Blood Institute
Pengobatan
Mengurangi jumlah lemak dalam darah dapat dicegah dengan selalu bergaya hidup sehat, menjauhi lemak jenuh yang berlebihan, sering berolahraga, mengurangi minuman beralkohol, dan mengurangi kelebihan berat badan.
Artikel terkait : Cara Mengobati Kolesterol Tinggi
Nah, apakah ukuran kolesterol anda sudah menunjukkan angka yang aman??
Berapakah kadar kolesterol normal yang benar meetdoctor jan berapakah sebenarnya kadar kolesterol yang normal apakah atau dan cara menghitungnya bagaimana apakah kadar kolesterol saya normal artikel kesehatan dari medicastore tentang mengetahui kadar kolesterol anda sangat penting untuk mengetahui apakah kadar kolesterol darah kita normal perempuan waspadalah terhadap penyakit jantung dan pembuluh darah kadar kolesterol normal wanita dewasa berapa kadar kolesterol mar kolesterol merupakan lemak yang ada di dalam Kolesterol Normal pembuluh darah manusia kolesterol merupakan lemak yang sangat berguna sebagai salah batas kolesterol normal mengecek dan menurunkan kadar Kolesterol okt batas kolesterol normal kadar.
Kolesterol yang normal berkisar antara dan mg dl jika tingkat.
Kumpulan.info - Kolesterol dalam tubuh dapat menyebabkan berbagai penyakit. Kolesterol yang tinggi tidak hanya dialami oleh orang yang bertubuh gemuk, tapi orang yang kurus tidak berarti kolesterolnya rendah. Ini juga dapat menimpa orang-orang yang masih muda. Berbagai kalangan umur, harus berusaha menjalani pola hidup yang sehat agar dapat menjaga kolesterol dalam darahnya tetap normal.
Kolesterol
Dalam tubuh terdapat lemak terdiri dari kolesterol jahat yang biasa disebut LDL (Low Density Lipoprotein) dimana lemak ini dapat menempel pada pembuluh darah. Sedangkan kolesterol baik yang dikenal dengan HDL (High Density Lipoprotein) merupakan lemak yang dapat melarutkan kandungan LDL dalam tubuh. Kolesterol normal dalam tubuh adalah 160-200 mg, maka penumpukan kandungan LDL harus dicegah agar tetap dalam keadaan normal. Berikut beberapa tips agar Anda dapat mengontrol kolesterol dalam darah.
Tips Mengendalikan Kolesterol
Berikut ini beberapa tips yang bisa Anda lakukan untuk mengendalikan kolesterol Anda:
Diet
Konsumsi makanan yang rendah lemak dan kolesterol. Misalnya dengan mengkonsumsi susu tanpa lemak dan mengurangi konsumsi daging. Pilihlah makanan dengan kandungan lemak tak jenuh daripada kandungan lemak jenuh. Minyak yang digunakan untuk menggoreng secara berulang-ulang dapat meningkatkan kadar kolesterol, maka ada baiknya Anda mengurangi konsumsi makanan yang digoreng.
Konsumsi makanan berserat
Lebih banyak mengkonsumsi makanan berserat seperti gandum, kacang-kacangan, sayur-sayuran dan buah-buahan. Jenis makanan ini dapat menyerap kolesterol yang ada dalam darah dan mengeluarkannya dari tubuh.
Konsumsi antioksidan
Antioksidan banyak terdapat dalam buah-buahan seperti jeruk, strawbery, pepaya, wortel, atau labu. Mengkonsumsi bawang putih secara teratur juga dapat menurunkan kadar kolesterol.
Hindari alkohol dan merokok
Dengan merokok atau mengkonsumsi alkohol, kolesterol akan mudah menumpuk dalam aliran darah.
Olahraga
Berolahraga secara teratur sesuai dengan umur dan kemampuan. Jaga agar berat tubuh Anda tetap ideal.
Makanan sehat, hati-hati, berbahaya atau pantang?
Seperti disebutkan diatas, makanan merupakan hal penting yang dapat menyebabkan kolesterol. Tabel berikut dapat Anda jadikan acuan makanan apa saja yang sebaiknya Anda makan atau dapat dikurangi konsumsinya.
Jenis Makanan
Kolestrol (mg/10 gr)
Kategori
Jenis makanan yang aman dikonsumsi karena kadar kolestrol yang rendah
Putih telur ayam
0
sehat
Teripang
0
sehat
Susu sapi non fat
0
sehat
Daging ayam / daging bebek pilihan tanpa kulit
50
sehat
Ikan air tawar
55
sehat
Daging sapi / daging babi pilihan tanpa lemak
60
sehat
Daging kelinci
65
sehat
Daging kambing tanpa lemak
70
sehat
Ikan ekor kuning
85
sehat
Jenis makanan yang boleh dikonsumsi sekali-kali
Daging asap (ham / smoke beef)
98
sekali-sekali
Iga sapi
100
sekali-sekali
Iga babi
105
sekali-sekali
Daging sapi
105
sekali-sekali
Burung dara
120
sekali-sekali
Ikan bawal
120
sekali-sekali
Jenis makanan yang perlu diperhatikan untuk dikonsumsi karena kadar kolestrol yang cukup tinggi
Daging sapi berlemak
125
hati-hati
Gajih sapi
130
hati-hati
Gajih kambing
130
hati-hati
Daging babi berlemak
130
hati-hati
Keju
140
hati-hati
Sosis daging
150
hati-hati
Kepiting
150
hati-hati
Udang
160
hati-hati
Kerang
160
hati-hati
Siput
160
hati-hati
Belut
185
hati-hati
Jenis makanan yang berbahaya untuk dikonsumsi karena kandungan kolestrol yang tinggi.
Santan
185
berbahaya
Gajih babi
200
berbahaya
Susu sapi
250
berbahaya
Susu sapi cream
280
berbahaya
Coklat
290
berbahaya
Margarin / Mentega
300
berbahaya
Jeroan sapi
380
berbahaya
Jeroan babi
420
berbahaya
Kerang putih / tiram
450
berbahaya
Jeroan kambing
610
berbahaya
Jenis makanan yang pantang untuk dikonsumsi karena kandungan kolestrol yang sangat tinggi.
Cumi-cumi
1170
pantang
Kuning telur ayam
2000
pantang
Otak sapi
2300
pantang
Otak babi
3100
pantang
Telur burung puyuh
3640
pantang
Tabel Jumlah Kolestrol pada Makanan
Catatan: Untuk kategori berbahaya dan pantang sebaiknya tidak dikonsumsi oleh penderita masalah hipertensi atau problem jantung, karena dapat menyebabkan serangan jantung, stroke dan bahkan kematian.
Berapa kadar gula darah yang normal penurun kolesterol obat kuat kadar gula darah yang normal berada pada angka kolesterol normal antara setelah berpuasa selama jam dan jam setelah gejala kolesterol dan cara menurunkan zona aneh jan meski demikian kadar normal kolesterol pada setiap orang tidaklah sama faktor yang sangat berpengaruh terhadap kadar kolesterol normal health corner kolesterol apa penyebab kolesterol tinggi mei kolesterol sangat penting untuk fungsi tubuh normal setiap sel dalam tubuh Kolesterol kita berapa kadar kolesterol normal jumlah kolesterol dalam kadar kolesterol normal untuk ibu hamil by menaikkan trombosit ags kadar kolesterol normal dapat kolesterol normalnya berapa mengkonsumsi ketahui gejala gejala dan.
Kadar normal hamil menurut kadar kolesterol normal berapa kadar tabel jumlah kolestrol pada makanan katering kesehatan dan diet ags dan apakah kolesterol saya bisa turun ke level normal kalau remaja usia tahun berapa jumlah kolesterol yg ideal dalam tubuh perlukah anda khawatir dengan kolesterol yang tinggi kolesterol normal manusia selama oleh karena itu penting ibu hamil mengetahui berapa besar peningkatan dalam pedoman kadar normal masih menggunakan kadar kolestrol kurang dari tahukah anda berapa banyak kolesterol yang aman untuk anda feb bagi mereka yang kadar trigliserida darahnya tinggi tetapi kadar kolesterol normal atau agak tinggi maka konsumsi lemak karbohidrat dan kolestrol kolesterol normal berapa saya adalah tinggi tidak!! ibu kolesterol normal dalam darah damia darwish apr ldl cholesterol adalah kolestrol jahat yang musti dihapuskan sepatutnya tak bole lebih dari ko tengok dah berapa aku lebih tes kesehatan oocities apabila ternyata kolesterol anda berada. Di luar batas normal segera lakukan perubahan gaya hidup tanda tanda vital.
Dan berapa angka yang normal consultation topic obat penurun kolesterol tanyadokter discussion sai berapa lama batas konsumsi obat tersebut saya ingin. Mengontrol kadar kolesterol saya supaya tidak melebihi normal.
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Microscopic appearance of cholesterol crystals in water. Photo taken under polarized light.
Cholesterol, from the Ancient Greek chole- (bile) and stereos (solid) followed by the chemical suffix -ol for an alcohol, is an organic molecule. It is a sterol (or modified steroid),[4] a lipid molecule and is biosynthesized by all animal cells because it is an essential structural component of all animal (not plant or bacterial) cell membranes that is required to maintain both membrane structural integrity and fluidity. Cholesterol enables animal cells to dispense with a cell wall (to protect membrane integrity and cell viability) thus allowing animal cells to change shape and animals to move (unlike bacteria and plant cells which are restricted by their cell walls).
In addition to its importance for animal cell structure, cholesterol also serves as a precursor for the biosynthesis of steroid hormones and bile acids.[5] Cholesterol is the principal sterol synthesized by all animals. In vertebrates the hepatic cells typically produce greater amounts than other cells. It is absent among prokaryotes (bacteria and archaea), although there are some exceptions such as Mycoplasma, which require cholesterol for growth.[6]
François Poulletier de la Salle first identified cholesterol in solid form in gallstones in 1769. However, it was not until 1815 that chemist Michel Eugène Chevreul named the compound "cholesterine".[7][8]
Physiology
Since cholesterol is essential for all animal life, each cell synthesizes it through a complex 37 step process beginning with the mevalonate pathway and ending with a 19 step conversion of lanosterol to cholesterol.
A human male weighing 68 kg (150 lb) normally synthesises about 1 g (1,000 mg) per day, and his body contains about 35 g, mostly contained within the cell membranes. Typical daily cholesterol dietary intake for a man in the United States is 307 mg (above the upper limit recommended by the Dietary Guidelines Advisory Committee[9]). However ingested cholesterol has little effect on body cholesterol because (a) cholesterol in foods is poorly absorbed and (b) any changes in intake are compensated for by alternations in internal body production; the reason that high animal food intake does not result in high cholesterol values. In addition, cholesterol ingestion, though transported in extracellular water (like all fats) within lipoproteins, do not significantly alter lipoprotein concentrations in unhealthy ways such as carbohydrates commonly do.
Most ingested cholesterol is esterified, and esterified cholesterol is poorly absorbed. The body also compensates for any absorption of additional cholesterol by reducing cholesterol synthesis.[10] For these reasons, cholesterol in food, seven to ten hours after ingestion, has little, if any effect on concentrations of cholesterol in the blood. However, during the first seven hours after ingestion of cholesterol, as absorbed fats are being distributed around the body within extracellular water by the various lipoproteins (which transport all fats in the water outside cells), the concentrations increase.[11] It is also important to recognize, however, that the concentrations measured in the blood plasma of samples vary with the measurement methods used. Traditional, simpler, cheaper methods do not reflect (a) in which lipoproteins the various fat molecules are being transported or (b) which cells are ingesting, burning or exporting the fats molecules being measured as totals from samples of blood plasma.
Cholesterol is recycled in the body. The liver excretes it in a non-esterified form (via bile) into the digestive tract. Typically, about 50% of the excreted cholesterol is reabsorbed by the small bowel back into the bloodstream.
Plants make cholesterol in very small amounts.[12] Plants manufacture phytosterols (substances chemically similar to cholesterol produced within plants), which can compete with cholesterol for reabsorption in the intestinal tract, thus potentially reducing cholesterol reabsorption.[13] When intestinal lining cells absorb phytosterols, in place of cholesterol, they usually excrete the phytosterol molecules back into the GI tract, an important protective mechanism.
Function
Cholesterol, given that it composes about 30% of all animal cell membranes, is required to build and maintain membranes; and modulates membrane fluidity over the range of physiological temperatures. The hydroxy group on cholesterol interacts with the polar head groups of the membrane phospholipids and sphingolipids, while the bulky steroid and the hydrocarbon chain are embedded in the membrane, alongside the nonpolar fatty-acid chain of the other lipids. Through the interaction with the phospholipid fatty-acid chains, cholesterol increases membrane packing, which both:
(a) alters membrane fluidity[14] and
(b) maintains membrane integrity so that animal cells do not need to build cell walls (like plants and most bacteria)
allowing animal cells to change shape and animals to move. The structure of the tetracyclic ring of cholesterol contributes to the fluidity of the cell membrane as the molecule is in a trans conformation making all but the side chain of cholesterol rigid and planar.[15] In this structural role, cholesterol also reduces the permeability of the plasma membrane to neutral solutes,[16]hydrogen ions, and sodium ions.[17]
Within the cell membrane, cholesterol also functions in intracellular transport, cell signaling and nerve conduction. Cholesterol is essential for the structure and function of invaginated caveolae and clathrin-coated pits, including caveola-dependent and clathrin-dependent endocytosis. The role of cholesterol in such endocytosis can be investigated by using methyl beta cyclodextrin (MCD) to remove cholesterol from the plasma membrane. Recent studies show that cholesterol is also implicated in cell signaling processes, assisting in the formation of lipid rafts in the plasma membrane. Lipid raft formation brings receptor proteins in close proximity with high concentrations of second messenger molecules.[18] Cholesterol & phospholipids, both electrical insulators, in multiple layers, can facilitate speed of transmission of electrical impulses along nerve tissue. For many neuron fibers, a myelin sheath, rich in cholesterol, since it is derived from compacted layers of Schwann cell membrane, provides insulation for more efficient conduction of impulses.[19]Demyelination (loss of some of these schwann cells) is believed to be part of the basis for multiple sclerosis.
Within cells, cholesterol is also a precursor molecule for several biochemical pathways. For example, it is the precursor molecule for the synthesis of vitamin D and all steroid hormones, including the adrenal gland hormones cortisol and aldosterone, as well as the sex hormones progesterone, estrogens, and testosterone, and their derivatives.[5]
The liver excretes cholesterol into biliary fluids, which is then stored in the gallbladder. Bile contains bile salts, which solubilize fats in the digestive tract and aid in the intestinal absorption of fat molecules as well as the fat-soluble vitamins, A, D, E, and K.
Some research indicates cholesterol may act as an antioxidant.[20]
Dietary sources
Animal fats are complex mixtures of triglycerides (stored energy, see: "Introduction to Energy Storage".), with lesser amounts of both the phospholipids and cholesterol molecules from which all animal (and human) cell membranes are constructed. Since all animal cells manufacture cholesterol, all animal based foods contain cholesterol in varying amounts.[21] Major dietary sources of cholesterol include cheese, egg yolks, beef, pork, poultry, fish, and shrimp.[22] Human breast milk also contains significant quantities of cholesterol.[23]
From a dietary perspective, because plant cells do not manufacture cholesterol, it is not found in plant based foods.[22][24] This has long been a basis for promoting that plant based foods must be healthier; concept and evidence contrary to the Paleolithic diet marketing.
Some plant based products such as avocado,[25]flax seeds and peanuts contain cholesterol-like compounds called phytosterols, which are believed to compete with cholesterol for absorption in the intestines, reducing the absorption of both dietary and bile cholesterol.[26]
Phytosterols can be supplemented through the use of phytosterol-containing functional foods or nutraceuticals that are recognized as having LDL-cholesterol (more relevant LDL-P responses not studied) lowering efficacy,.[27] This data does not reflect actual changes in LDL particle concentrations and has not been evaluated for cardiovascular disease outcomes. Some supplemental guidelines have recommend doses of phytosterols in the 1.6-3.0 grams per day range (Health Canada, EFSA, ATP III,FDA) with a recent meta-analysis demonstrating an 8.8% reduction in LDL-cholesterol at a mean dose of 2.15 gram per day.[28] However, the benefits of a diet supplemented with phytosterol has been questioned.[29][30] and evidence exists that absorbed plant phytosterols are much more atherogenic than animal cholesterol.
The fraction of cholesterol in the intestines which is absorbed varies from 15% to 75%, and group averages are about 50%, with the remainder excreted in the feces.[31] However absorbed cholesterol is mostly cholesterol which was excreted by the liver into the bile, not from food, the reason, for homeostatic reasons, that eating high cholesterol foods, e.g. Atkins, does not result in high blood cholesterol concentrations. Free cholesterol is much more likely to be absorbed than esterified cholesterol, and the proportion of free versus esterified cholesterol varies between different food sources.[32] In February 2015, reversing decades-long recommendations, the USDA Dietary Guidelines Advisory Committee recommended repealing the guideline that Americans limit cholesterol intake, because dietary cholesterol intake has never correlated well with serum cholesterol levels. The committee looked for and found evidence that replacing saturated fat with unsaturated fat could lower LDL-cholesterol levels, and that low-fat diets which replaced saturated fat with carbohydrates could lower both LDL-cholesterol (LDL-P not evaluated) and HDL-cholesterol (HDL-P not evaluated) concentrations.[33]Trans fats have been shown to reduce levels of HDL while increasing levels of LDL.[34] Based on such evidence and evidence implicating low HDL-C and high LDL-C levels in cardiovascular disease (see Hypercholesterolemia), many health authorities advocate reducing LDL-cholesterol through changes in diet in addition to other lifestyle modifications.[35] However, be aware that (a) LDL-C is always a calculated estimate and NOT measured LDL-P, (b) HDL-C is NOT measured HDL-P and that (c) outcome data has always tracked particle concentrations, not cholesterol values per-se.
Increased dietary intake of industrial trans fats is associated with an increased risk in all-cause mortality, cardiovascular diseases or type 2 diabetes.[36]
Biosynthesis
All animal cells manufacture cholesterol, for both membrane structure and other uses, with relative production rates varying by cell type and organ function. About 20% of total daily cholesterol production occurs in the liver; other sites of higher synthesis rates include the intestines, adrenal glands, and reproductive organs. Synthesis within the body starts with the mevalonate pathway where two molecules of acetyl CoA condense to form acetoacetyl-CoA. This is followed by a second condensation between acetyl CoA and acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl CoA (HMG-CoA).[37] This molecule is then reduced to mevalonate by the enzyme HMG-CoA reductase. Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins (a class of cholesterol lowering drugs).
Mevalonate is finally converted to isopentenyl pyrophosphate (IPP) through two phosphorylation steps and one decarboxylation step that requires ATP. Three molecules of isopentenyl pyrophosphate condense to form farnesyl pyrophosphate through the action of geranyl transferase. Two molecules of farnesyl pyrophosphate then condense to form squalene by the action of squalene synthase in the endoplasmic reticulum.[37] Oxidosqualene cyclase then cyclizes squalene to form lanosterol. Finally, lanosterol is converted to cholesterol through a 19-step process.[38][39]
Konrad Bloch and Feodor Lynen shared the Nobel Prize in Physiology or Medicine in 1964 for their discoveries concerning some of the mechanisms and methods of regulation of cholesterol and fatty acid metabolism, though lots of complexities remain to be sorted out.
Regulation of cholesterol synthesis
Biosynthesis of cholesterol is directly regulated by the cholesterol levels present, though the homeostatic mechanisms involved are only partly understood. A higher intake from food leads to a net decrease in endogenous production, whereas lower intake from food has the opposite effect. The main regulatory mechanism is the sensing of intracellular cholesterol in the endoplasmic reticulum by the protein SREBP (sterol regulatory element-binding protein 1 and 2).[40] In the presence of cholesterol, SREBP is bound to two other proteins: SCAP (SREBP cleavage-activating protein) and INSIG-1. When cholesterol levels fall, INSIG-1 dissociates from the SREBP-SCAP complex, which allows the complex to migrate to the Golgi apparatus. Here SREBP is cleaved by S1P and S2P (site-1 protease and site-2 protease), two enzymes that are activated by SCAP when cholesterol levels are low.
The cleaved SREBP then migrates to the nucleus, and acts as a transcription factor to bind to the sterol regulatory element (SRE), which stimulates the transcription of many genes. Among these are the low-density lipoprotein (LDL) receptor and HMG-CoA reductase. The LDL receptor scavenges circulating LDL from the bloodstream, whereas HMG-CoA reductase leads to an increase of endogenous production of cholesterol.[41] A large part of this signaling pathway was clarified by Dr. Michael S. Brown and Dr. Joseph L. Goldstein in the 1970s. In 1985, they received the Nobel Prize in Physiology or Medicine for their work. Their subsequent work shows how the SREBP pathway regulates expression of many genes that control lipid formation and metabolism and body fuel allocation.
Cholesterol synthesis can also be turned off when cholesterol levels are high. HMG-CoA reductase contains both a cytosolic domain (responsible for its catalytic function) and a membrane domain. The membrane domain senses signals for its degradation. Increasing concentrations of cholesterol (and other sterols) cause a change in this domain's oligomerization state, which makes it more susceptible to destruction by the proteosome. This enzyme's activity can also be reduced by phosphorylation by an AMP-activated protein kinase. Because this kinase is activated by AMP, which is produced when ATP is hydrolyzed, it follows that cholesterol synthesis is halted when ATP levels are low.[42]
Plasma transport and regulation of absorption
See also: Blood lipids
Lipid logistics: transport of triglycerides and cholesterol in organisms in form of lipoproteins as chylomicrons, VLDL, LDL, IDL, HDL.
As an isolated molecule, cholesterol is only minimally soluble in water; it dissolves into the (water-based) bloodstream only at exceedingly small concentrations. Instead, cholesterol is transported within lipoproteins, complex discoidal particles with exterior amphiphilic proteins and lipids, whose outward-facing surfaces are water-soluble and inward-facing surfaces are lipid-soluble; i.e. transport via emulsification. Triglycerides and cholesterol esters are carried internally. Phospholipids and cholesterol, being amphipathic, are transported in the monolayer surface of the lipoprotein particle.
There are several types of lipoproteins in the blood. In order of increasing density, they are chylomicrons, very-low-density lipoprotein (VLDL),intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL). Lower protein/lipid ratios make for less dense lipoproteins. Cholesterol within different lipoproteins is identical, although some is carried as its native "free" alcohol form (the cholesterol-OH group facing the water surrounding the particles), while others as fatty acyl esters, known also as cholesterol esters, within the particles.
Lipoprotein particles are organized by complex apolipoproteins, typically 80-100 different proteins per particle, which can be recognized and bound by specific receptors on cell membranes, directing their lipid payload into specific cells and tissues currently ingesting these fat transport particles. Lipoprotein particles thus include a molecular addresses which play key roles in distribution and delivery of fats around the body in the water outside cells.
Chylomicrons, the least dense cholesterol transport molecules, contain apolipoprotein B-48, apolipoprotein C, and apolipoprotein E in their shells. Chylomicrons carry fats from the intestine to muscle and other tissues in need of fatty acids for energy or fat production. Unused cholesterol remains in more cholesterol-rich chylomicron remnants, and taken up from here to the bloodstream by the liver.
VLDL molecules are produced by the liver from triacylglycerol and cholesterol which was not used in the synthesis of bile acids. These molecules contain apolipoprotein B100 and apolipoprotein E in their shells, and are degraded by lipoprotein lipase on the blood vessel wall to IDL.
Blood vessels cleave and absorb triacylglycerol from IDL molecules, increasing the concentration of cholesterol. IDL molecules are then consumed in two processes: half is metabolized by HTGL and taken up by the LDL receptor on the liver cell surfaces, while the other half continues to lose triacylglycerols in the bloodstream until they become LDL molecules, with the highest concentration of cholesterol within them.
LDL particles are the major blood cholesterol carriers. Each one contains approximately 1,500 molecules of cholesterol ester. LDL molecule shells contain just one molecule of apolipoprotein B100, recognized by LDL receptors in peripheral tissues. Upon binding of apolipoprotein B100, many LDL receptors concentrate in clathrin-coated pits. Both LDL and its receptor form vesicles within a cell via endocytosis. These vesicles then fuse with a lysosome, where the lysosomal acid lipase enzyme hydrolyzes the cholesterol esters. The cholesterol can then be used for membrane biosynthesis or esterified and stored within the cell, so as to not interfere with the cell membranes.
LDL receptors are used up during cholesterol absorption, and its synthesis is regulated by SREBP, the same protein that controls the synthesis of cholesterol de novo, according to its presence inside the cell. A cell with abundant cholesterol will have its LDL receptor synthesis blocked, to prevent new cholesterol in LDL molecules from being taken up. Conversely, LDL receptor synthesis proceeds when a cell is deficient in cholesterol.
When this process becomes unregulated, LDL molecules without receptors begin to appear in the blood. These LDL molecules are oxidized and taken up by macrophages, which become engorged and form foam cells. These foam cells often become trapped in the walls of blood vessels and contribute to atherosclerotic plaque formation. Differences in cholesterol homeostasis affect the development of early atherosclerosis (carotid intima-media thickness).[43] These plaques are the main causes of heart attacks, strokes, and other serious medical problems, leading to the association of so-called LDL cholesterol (actually a lipoprotein) with "bad" cholesterol.[42]
HDL particles are thought to transport cholesterol back to the liver, either for excretion or for other tissues that synthesize hormones, in a process known as reverse cholesterol transport (RCT).[44] Large numbers of HDL particles correlates with better health outcomes.,[45] whereas low numbers of HDL particles is associated with atheromatous disease progression in the arteries.
Metabolism, recycling and excretion
Cholesterol is susceptible to oxidation and easily forms oxygenated derivatives known as oxysterols. Three different mechanisms can form these; autoxidation, secondary oxidation to lipid peroxidation, and cholesterol-metabolizing enzyme oxidation. A great interest in oxysterols arose when they were shown to exert inhibitory actions on cholesterol biosynthesis.[46] This finding became known as the oxysterol hypothesis. Additional roles for oxysterols in human physiology include their: participation in bile acid biosynthesis, function as transport forms of cholesterol, and regulation of gene transcription.[47]
In biochemical experiments radiolabelled forms of cholesterol, such as tritiated-cholesterol are used. These derivatives undergo degradation upon storage and it is essential to purify cholesterol prior to use. Cholesterol can be purified using small Sephadex LH-20 columns.[48]
Cholesterol is oxidized by the liver into a variety of bile acids.[49] These, in turn, are conjugated with glycine, taurine, glucuronic acid, or sulfate. A mixture of conjugated and nonconjugated bile acids, along with cholesterol itself, is excreted from the liver into the bile. Approximately 95% of the bile acids are reabsorbed from the intestines, and the remainder are lost in the feces.[50] The excretion and reabsorption of bile acids forms the basis of the enterohepatic circulation, which is essential for the digestion and absorption of dietary fats. Under certain circumstances, when more concentrated, as in the gallbladder, cholesterol crystallises and is the major constituent of most gallstones. Although, lecithin and bilirubin gallstones also occur, but less frequently.[51] Every day, up to 1 g of cholesterol enters the colon. This cholesterol originates from the diet, bile, and desquamated intestinal cells, and can be metabolized by the colonic bacteria. Cholesterol is converted mainly into coprostanol, a nonabsorbable sterol that is excreted in the feces. A cholesterol-reducing bacterium origin has been isolated from human feces.[52][non-primary source needed]
Although cholesterol is a steroid generally associated with mammals, the human pathogen Mycobacterium tuberculosis is able to completely degrade this molecule and contains a large number of genes that are regulated by its presence.[53] Many of these cholesterol-regulated genes are homologues of fatty acid -oxidation genes, but have evolved in such a way as to bind large steroid substrates like cholesterol.[54][55]
Molecular actions
Cholesterol has been found to bind to and affect the gating of a number of ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.[56]
Clinical significance
Hypercholesterolemia
Main articles: hypercholesterolemia and lipid hypothesis
Cholesterolemia and mortality for men and women <50 years and >60 years
According to the lipid hypothesis, since cholesterol (like all fat molecules) is transported around the body (in the water outside cells) inside lipoprotein particles, elevated cholesterol concentrations (hypercholesterolemia) potentially offers a lower cost way to estimate concentrations of LDL particles; possibly even low concentrations of functional HDL particles both variations strongly associated with cardiovascular disease because LDL particles promote atheroma development in arteries (atherosclerosis).
The problem with this hypothesis is that a single LDL-particle typically carries 3,000 to 6,000 fat molecules and the percentage which are cholesterol (vs. all other fat molecules) is: (a) highly variable, (b) not measured (only guessed at) by lipid tests, (c) correlates better only when cholesterol concentrations are very high, over 350 mg/dL, and (d) the majority of individuals who suffer heart attacks, strokes and peripheral arterial disease complications have "normal" cholesterol values, i.e. values <200 mg/dL.
This atherosclerotic disease process, over decades, leads to myocardial infarction (heart attack), stroke, and peripheral vascular disease. Since higher blood LDL, especially higher LDL particle concentrations and smaller LDL particle size, contribute to this process more than the cholesterol content of the HDL particles,[57] LDL particles are often termed "bad cholesterol" because they have been linked to atheroma formation. On the other hand, high concentrations of functional HDL, which can remove cholesterol from cells and atheroma, offer protection and are sometimes referred to as "good cholesterol". These balances are mostly genetically determined, but can be changed by body build, medications, food choices,[58] and other factors.[59]
Conditions with elevated concentrations of oxidized LDL particles, especially "small dense LDL" (sdLDL) particles, are associated with atheroma formation in the walls of arteries, a condition known as atherosclerosis, which is the principal cause of coronary heart disease and other forms of cardiovascular disease. In contrast, HDL particles (especially large HDL) have been identified as a mechanism by which cholesterol and inflammatory mediators can be removed from atheroma. Increased concentrations of HDL correlate with lower rates of atheroma progressions and even regression. A 2007 study pooling data on almost 900,000 subjects in 61 cohorts demonstrated that blood total cholesterol levels have an exponential effect on cardiovascular and total mortality, with the association more pronounced in younger subjects. Still, because cardiovascular disease is relatively rare in the younger population, the impact of high cholesterol on health is still larger in older people.[60]
Elevated levels of the lipoprotein fractions, LDL, IDL and VLDL are regarded as atherogenic (prone to cause atherosclerosis).[61] Levels of these fractions, rather than the total cholesterol level, correlate with the extent and progress of atherosclerosis. Conversely, the total cholesterol can be within normal limits, yet be made up primarily of small LDL and small HDL particles, under which conditions atheroma growth rates would still be high. Recently, a post hoc analysis of the IDEAL and the EPIC prospective studies found an association between high levels of HDL cholesterol (adjusted for apolipoprotein A-I and apolipoprotein B) and increased risk of cardiovascular disease, casting doubt on the cardioprotective role of "good cholesterol".[62]
Elevated cholesterol levels are treated with a strict diet consisting of low saturated fat, trans fat-free, low cholesterol foods,[63][64] often followed by one of various hypolipidemic agents, such as statins, fibrates, cholesterol absorption inhibitors, nicotinic acid derivatives or bile acid sequestrants.[65] Extreme cases have previously been treated with partial ileal bypass surgery, which has now been superseded by medication. Apheresis-based treatments are still used for very severe hyperlipidemias that are either unresponsive to treatment or require rapid lowering of blood lipids.[66]
Multiple human trials using HMG-CoA reductase inhibitors, known as statins, have repeatedly confirmed that changing lipoprotein transport patterns from unhealthy to healthier patterns significantly lowers cardiovascular disease event rates, even for people with cholesterol values currently considered low for adults.[67] Studies have also found that statins reduce atheroma progression.[68] As a result, people with a history of cardiovascular disease may derive benefit from statins irrespective of their cholesterol levels (total cholesterol below 5.0 mmol/L [193 mg/dL]),[69] and in men without cardiovascular disease, there is benefit from lowering abnormally high cholesterol levels ("primary prevention").[70] Primary prevention in women was originally practiced only by extension of the findings in studies on men,[71] since, in women, none of the large statin trials conducted prior to 2007 demonstrated a statistically significant reduction in overall mortality or in cardiovascular endpoints.[72] In 2008, a large clinical trial reported that, in apparently healthy adults with increased levels of the inflammatory biomarker high-sensitivity C-reactive protein but with low initial LDL, 20 mg/day of rosuvastatin for 1.9 years resulted in a 44% reduction in the incidence of cardiovascular events and a 20% reduction in all-cause mortality; the effect was statistically significant for both genders.[73] Though this result was met with some skepticism, later studies and meta-analyses likewise demonstrated statistically significant (but smaller) reductions in all-cause and cardiovascular mortality, without significant heterogeneity by gender.[74]
Level mg/dL
Level mmol/L
Interpretation
< 200
< 5.2
Desirable level corresponding to lower risk for heart disease
200240
5.26.2
Borderline high risk
> 240
> 6.2
High risk
The 1987 report of National Cholesterol Education Program, Adult Treatment Panels suggests the total blood cholesterol level should be: < 200 mg/dL normal blood cholesterol, 200239 mg/dL borderline-high, > 240 mg/dL high cholesterol.[75] The American Heart Association provides a similar set of guidelines for total (fasting) blood cholesterol levels and risk for heart disease:[76]
However, as today's testing methods determine LDL ("bad") and HDL ("good") cholesterol separately, this simplistic view has become somewhat outdated. The desirable LDL level is considered to be less than 100 mg/dL (2.6 mmol/L),[77] although a newer upper limit of 70 mg/dL (1.8 mmol/L) can be considered in higher-risk individuals based on some of the above-mentioned trials. A ratio of total cholesterol to HDLanother useful measureof far less than 5:1 is thought to be healthier.
Reference ranges for blood tests, showing usual, as well as optimal, levels of HDL, LDL and total cholesterol in mass and molar concentrations, is found in orange color at right, that is, among the blood constituents with the highest concentration.
Total cholesterol is defined as the sum of HDL, LDL, and VLDL. Usually, only the total, HDL, and triglycerides are measured. For cost reasons, the VLDL is usually estimated as one-fifth of the triglycerides and the LDL is estimated using the Friedewald formula (or a variant): estimated LDL = [total cholesterol] [total HDL] [estimated VLDL]. VLDL can be calculated by dividing total triglycerides by five. Direct LDL measures are used when triglycerides exceed 400 mg/dL. The estimated VLDL and LDL have more error when triglycerides are above 400 mg/dL.[78]
Given the well-recognized role of cholesterol in cardiovascular disease, some studies have shown an inverse correlation between cholesterol levels and mortality. A 2009 study of patients with acute coronary syndromes found an association of hypercholesterolemia with better mortality outcomes.[79] In the Framingham Heart Study, in subjects over 50 years of age, they found an 11% increase overall and 14% increase in cardiovascular disease mortality per 1 mg/dL per year drop in total cholesterol levels. The researchers attributed this phenomenon to the fact that people with severe chronic diseases or cancer tend to have below-normal cholesterol levels.[80] This explanation is not supported by the Vorarlberg Health Monitoring and Promotion Programme, in which men of all ages and women over 50 with very low cholesterol were likely to die of cancer, liver diseases, and mental diseases. This result indicates the low-cholesterol effect occurs even among younger respondents, contradicting the previous assessment among cohorts of older people that this is a proxy or marker for frailty occurring with age.[81]
The vast majority of doctors and medical scientists consider that there is a link between cholesterol and atherosclerosis as discussed above;[82] a small group of scientists, united in The International Network of Cholesterol Skeptics, questions the link.[83] A 2014 meta analysis which followed over 500,000 patients, concluded there is insufficient evidence to support the recommendation of high consumption of polyunsaturated fatty acids and low consumption of total saturated fats for cardiovascular health.[84]
Hypocholesterolemia
Abnormally low levels of cholesterol are termed hypocholesterolemia. Research into the causes of this state is relatively limited, but some studies suggest a link with depression, cancer, and cerebral hemorrhage. In general, the low cholesterol levels seem to be a consequence, rather than a cause, of an underlying illness.[60] A genetic defect in cholesterol synthesis causes Smith-Lemli-Opitz syndrome, which is often associated with low plasma cholesterol levels. Hyperthyroidism, or any other endocrine disturbance which causes upregulation of the LDL receptor may result in hypocholesterolaemia.[85]
Cholesterol testing
The American Heart Association recommends testing cholesterol every five years for people aged 20 years or older.[86] A separate set of American Heart Association guidelines issued in 2013 indicates that patients taking statin medications should have their cholesterol tested 412 weeks after their first dose and then every 312 months thereafter.[87]
A blood sample after 12-hour fasting is taken by a doctor, or a home cholesterol-monitoring device is used to determine a lipoprotein profile. This measures total cholesterol, LDL (bad) cholesterol, HDL (good) cholesterol, and triglycerides. It is recommended to test cholesterol at least every five years if a person has total cholesterol of 5.2 mmol/L or more (200+ mg/dL), or if a man over age 45 or a woman over age 50 has HDL (good) cholesterol less than 1 mmol/L (40 mg/dL), or there are other risk factors for heart disease and stroke. Other risk factors for heart disease include Diabetes, Hypertension (or use of anti-hypertensive medications), low HDL, family history of CAD and hypercholesterolemia, and cigarette smoking.[88]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
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Statin Pathway edit
^The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".
Cholesteric liquid crystals
Some cholesterol derivatives (among other simple cholesteric lipids) are known to generate the liquid crystalline "cholesteric phase". The cholesteric phase is, in fact, a chiral nematic phase, and it changes colour when its temperature changes. This makes cholesterol derivatives useful for indicating temperature in liquid crystal display thermometers and in temperature-sensitive paints.
Stereoisomers
Cholesterol has 256 stereoisomers that arise from its 8 stereocenters, although only two of the stereoisomers are of biochemical significance (nat-cholesterol and ent-cholesterol, for natural and enantiomer, respectively),[89][90] and only one occurs naturally (nat-cholesterol).
See also
Arcus senilis "Cholesterol ring" in the eyes
Cardiovascular disease
Cholesterol embolism
Cholesterol total synthesis
Familial hypercholesterolemia
List of cholesterol in foods
NiemannPick disease Type C
Oxycholesterol
Additional images
Cholesterol units conversion
Steroidogenesis, using cholesterol as building material
Space-filling model of the Cholesterol molecule
Numbering of the steroid nuclei
References
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External links
GMD MS Spectrum
Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults US National Institutes of Health Adult Treatment Panel III
